RAS family

Definition:

Ras family is the most frequently mutated gene family in cancers. RAS is a small switch signalling GTPase that toggles between its Guanosine 5′-triphosphate (GTP)-bound active state and the GDP-bound inactive state.

References:

[1]. Amanda R Moore, et al. RAS-targeted therapies: is the undruggable drugged? Nat Rev Drug Discov. 2020 Aug;19(8):533-552. [Content Brief]

Biomedical Dictionary

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